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Title: [Randomized double-blind study comparing tissue-type plasminogen activator with placebo in acute myocardial infarct]
Authors: Bleifeld, W ×
Verstraete, Marc
Brower, R W
Collen, Desire
Dunning, A J
Lubsen, J
Michel, P L
Schofer, J
Vanhaecke, Johan
Van de Werf, Frans
Charbonnier, B
de Bono, D P
Lennane, R J
Mathey, D G
Raynaud, P
Vahanian, A
Van de Kley, G A
von Essen, R #
Issue Date: Jan-1988
Series Title: Klinische Wochenschrift vol:66 Suppl 12 pages:86-92
Abstract: In a double-blind randomised trial 129 patients with first myocardial infarction of less than 6 h duration were allocated to treatment with human recombinant tissue-type plasminogen activator (rt-PA) given intravenously over 90 min, or to placebo infusion. Coronary angiography at the end of this infusion showed that the infarct-related vessel was patent in 61% of 62 assessable coronary angiograms in the rt-PA-treated group compared with 21% in the control group. Treatment with rt-PA was not accompanied by any major complications. In the rt-PA group the circulating fibrinogen level at the end of the catheterisation was 52 +/- 29% (mean +/- SD) of the starting value.
ISSN: 0023-2173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
Faculty of Medicine - miscellaneous
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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