Title: Characterization and property of DNA incorporated bilayer lipid membranes
Authors: Tong, YH
Han, XJ
Song, Yonghai
Jiang, JG
Wang, EK # ×
Issue Date: Aug-2003
Publisher: Elsevier science bv
Series Title: Biophysical chemistry vol:105 issue:1 pages:1-9
Abstract: Calf-thymus DNA-incorporated bilayer lipid membranes supported on a glassy carbon (GC) electrode was prepared by making layers of phosphatidylcholine dimyristoyl (DMPC) on GC electrode. DNA in the BLM was characterized by cyclic voltammetry, IR and AFM, and lipid layers formed on the GC electrode were demonstrated to be a bilayer lipid membrane by electrochemical impedance experiment. In IR and AFM experiments the findings indicated that DNA was incorporated into BLM. The ion channel of bilayer lipid membranes incorporated was studied. The result showed that the ion channel was opened in the presence of the stimulus quinacrine. In the absence of quinacrine the channel was switched. The process can repeat itself many times. The impedance spectroscopy measurements demonstrate that the stimulus quinacrine opens the channel for permeation of marker ion. The mechanism of forming an ion channel was investigated. (C) 2002 Elsevier B.V. All rights reserved.
ISSN: 0301-4622
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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