Title: Control of ecdysteroidogenesis in prothoracic glands of insects: a review
Authors: Marchal, Elisabeth ×
Vandersmissen, Hans Peter
Badisco, Liesbeth
Van de Velde, Sandrien
Verlinden, Heleen
Iga, Masatoshi
Van Wielendaele, Pieter
Huybrechts, Roger
Simonet, Gert
Smagghe, Guy
Vanden Broeck, Jozef #
Issue Date: 2010
Publisher: Elsevier
Series Title: Peptides vol:31 issue:3 pages:506-519
Abstract: The very first step in the study of the endocrine control of insect molting was taken in 1922.
Stefan Kopeć characterized a factor in the brain of the gypsy moth, Lymantria dispar which
appeared to be essential for metamorphosis. This factor was later identified as the
neuropeptide prothoracicotropic hormone (PTTH), the first discovery of a series of factors
involved in the regulation of ecdysteroid biosynthesis in insects. It is now accepted that PTTH
is the most important regulator of prothoracic gland (PG) ecdysteroidogenesis. The periodic
increases in ecdysteroid titer necessary for insect development can basically be explained by
the episodic activation of the PGs by PTTH. However, since the characterization of the
prothoracicostatic hormone (PTSH), it has become clear that in addition to ‘tropic factors’,
also ‘static factors’, which are responsible for the ‘fine-tuning’ of the hemolymph ecdysteroid
titer, are at play . Many of these regulatory factors are peptides originating from the brain, but
also other, extracerebral factors both of peptidic and non-peptidic nature are able to affect PG
ecdysteroidogenesis, such as the ‘classic’ insect hormones, juvenile hormone (JH) and the
molting hormone (20E) itself. The complex secretory pattern of ecdysteroids as observed in
vivo is the result of the delicate balance and interplay between these ecdysiotropic and
ecdysiostatic factors.
ISSN: 0196-9781
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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