Title: Bone and metabolism: a complex crosstalk
Authors: Lieben, Liesbet ×
Callewaert, Filip
Bouillon, Roger #
Issue Date: Jan-2009
Publisher: S. Karger
Series Title: Hormone Research vol:71 Suppl 1 pages:134-138
Abstract: BACKGROUND: Until recently, communication from metabolism to bone was considered purely unidirectional, involving complex interactions among an adipocyte-derived factor (leptin), the sympathetic nervous system and neuropeptides. However, studies in animal models now show that bone regulates glucose metabolism and fat mass via the uncarboxylated form of an osteoblast-derived factor (osteocalcin). These findings not only demonstrate that energy metabolism regulates bone remodeling through neural relays, but also that the skeleton acts as an endocrine tissue that regulates metabolic homeostasis. CONCLUSIONS: Further study is needed to understand the physiological role of these complex interactions in man and their implications for human diseases.
ISSN: 0301-0163
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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