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Title: Growth of cationic lipid toward bilayer, lipid membrane by solution spreading: scanning probe microscopy study
Authors: Wang, L
Song, Yonghai
Han, XJ
Zhang, BL
Wang, EK # ×
Issue Date: Apr-2003
Publisher: Elsevier sci ireland ltd
Series Title: Chemistry and physics of lipids vol:123 issue:2 pages:177-185
Abstract: The growth of cationic lipid dioctadecyldimethylammonium bromide (DODAB) toward bilayer lipid membrane (BLM) by solution spreading on cleaved mica surface was studied by atomic force microscopy (AFM). Bilayer of DODAB was formed by exposing mica to a solution of DODAB in chloroform and subsequently immersing into potassium chloride solution for film developing. AFM studies showed that at the initial stage of the growth, the adsorbed molecules exhibited the small fractal-like aggregates. These aggregates grew up and expanded laterally into larger patches with time and experienced from monolayer to bilayer, finally a close-packed bilayer film (5.4 +/- 0.2 nm) was approached. AFM results of the film growth process indicated a growth mechanism of nucleation, growth and coalescence of dense submonolayer, it revealed the direct information about the film morphology and confirmed that solution spreading was an effective technique to prepare a cationic bilayer in a short time. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
URI: 
ISSN: 0009-3084
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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