Title: Long-term efficacy of tiotropium in relation to smoking status in the UPLIFT trial
Authors: Tashkin, D P ×
Celli, B
Kesten, S
Lystig, T
Mehra, S
Decramer, Marc #
Issue Date: Feb-2010
Publisher: Published jointly by the Society and Munksgaard
Series Title: European Respiratory Journal vol:35 issue:2 pages:287-294
Abstract: UPLIFT, a 4-year trial of tiotropium in COPD, allowed for assessment of smoking status on long-term responses to maintenance bronchodilator therapy.5993 patients were randomized (tiotropium/placebo). Lung function, St. George's Respiratory Questionnaire (SGRQ), exacerbations and adverse events were followed. Patients were characterized as continuing smokers (CS), continuing ex-smokers (CE), or intermittent smokers (IS) based on self-reporting smoking behaviour.60%, 14% and 26% of patients were CE, CS, and IS. The rate of FEV1 decline for placebo patients was most rapid in CS (-51+/-4, -36+/-2, and -23+/-2ml.yr(-1) in CS, IS, and ES respectively). Tiotropium did not alter FEV1 decline, but was associated with significant improvements in pre&post-bronchodilator FEV1 over placebo that persisted throughout the 4-year trial for each smoking status (pre-bronchodilator: 125, 55, and 97 ml at 48 months, in CS, IS, CE, respectively; p<=0.0003). Tiotropium reduced exacerbation risk in CS (HR(95%CI) 0.81 (0.68-0.97)), in CE (0.86 (0.79-0.93)) and trended towards significance in IS (0.89 (0.80-1.01)). At four years, SGRQ for tiotropium patients improved the most in CS (-4.62 units, p=0.0006) and the least in IS (-0.54 units, p=0.55), compared with control.Tiotropium provided long-term benefits irrespective of smoking status, although differences among categories were observed.
ISSN: 0903-1936
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science