Title: Synthesis of new derivatives of 2,3-dicyano-imidazo [1,2-a] pyrimidine from 4-hydroxy-6-methylpyran-2-ones
Authors: El Otmani, Bouchaib ×
El Mahi, Mohammed
Bouhfid, Rachid
Essassi, El Mokhtar
Rohand, Taoufik
Dehaen, Wim
El Ammari, Lahcen #
Issue Date: 2008
Publisher: Arkat usa inc
Series Title: Arkivoc pages:59-70
Abstract: The reactions of 2-amino-4,5-dicyanoimidazole 1 with lactone 2 in refluxing alcohol has been carried out for the first time and afforded imidazo[1,2-a] pyrimidines 4 and 5a-d. Condensation of compound 1 with 3-acetyl-4-hydroxy-6-methylpyran-2-one in refluxing n-butanol afforded bis(imidazopyrimidine) derivative 6. Reaction of hydrazine hydrate with ester 5 yielded the corresponding hydrazides 8. Condensation of o-phenylenediamines 9 with compound 5 in refluxing xylene or with hydrazides by melting reagents afforded 2,3-dicyano-5-[benzimidazol-2-yl]methyl-7-methylimidazo[1,2-a] pyrimidines 10a-d.
ISSN: 1551-7004
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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