ITEM METADATA RECORD
Title: Functionalisation of artemisinin and its ring-contracted derivatives
Authors: Van Neck, Tine ×
Van Mierloo, Sarah
Dehaen, Wim #
Issue Date: Mar-2007
Publisher: Molecular diversity preservation international
Series Title: Molecules vol:12 issue:3 pages:395-405
Abstract: Isoxazoline analogues of artemisinin were obtained in low yield and low diastereoselectivity from the 1,3-dipolar cycloaddition of nitrile oxides. Alternatively, starting from the aldehyde 7, a number of transformations - Wittig reaction and reduction, Henry reaction and cyanohydrin formation - were achieved in significantly higher yields. In the cases where a new stereocenter was introduced this occured diastereoselectively.
ISSN: 1420-3049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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