Title: Reactions of malonthioamides and malonamidines with methyl acetylpyruvate as a one-step method to prepare 4-thio- and 4-aminopyrrolo[3,4-c]pyridines
Authors: Berseneva, Vera S ×
Bakulev, Vasiliy A
Dehaen, Wim
Toppet, Suzanne
Borovkova, Marina #
Issue Date: May-2007
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:63 issue:21 pages:4491-4496
Abstract: We report an efficient one-step approach to 4-thio and 4-aminopyrrolo[3,4-c]pyridines based on the selective reaction of malonthioamides and malonamidines with methyl acetylpyruvate. Structural proof is given by HMBC and HMQC spectra. A cascade heterocyclization mechanism is proposed for the reactions studied. (C) 2007 Elsevier Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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