Title: Dendritic nucleotides: interaction with an aliphatic acid monolayer
Authors: Wang, Guojie
Abramov, Mikhail
Van Aerschot, Arthur
Rozenski, Jef
Lei, Shengbin
Klymchenko, Andrei
Van der Auweraer, Mark
De Feyter, Steven
Herdewijn, Piet # ×
Issue Date: Sep-2008
Publisher: Verlag Helvetica Chimica Acta
Series Title: Chemistry & Biodiversity vol:5 issue:9 pages:1675-1682
Abstract: Dendrimeric-T and dendrimeric-A with 36 nucleotides were synthesized using phosphoramidite reagents. These dendrimers contain the nucleosides dA and dT, which are the components of the dA-dT base pair. Branching was obtained using a bifurcated and trifurcated reagent. The dendrimers were purified by ion-exchange chromatography. No specific interactions between these dendrimers were observed using atomic force microscopy. However, the dendrimeric-T is able to disrupt monolayers of fatty acids, resulting in a reorientation of the lipids (from head-to-tail to head-to-head) as demonstrated by scanning tunneling microscopy (STM).
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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