Title: Inverse Langmuir method for oligonucleotide microarray analysis
Authors: Mulders, Geert C. W. M ×
Barkema, Gerard T
Carlon, Enrico #
Issue Date: Feb-2009
Publisher: Biomed central ltd
Series Title: BMC Bioinformatics vol:10 pages:1-8
Article number: 64
Abstract: Background: An algorithm for the analysis of Affymetrix Genechips is presented. This algorithm, referred to as the Inverse Langmuir Method (ILM), estimates the binding of transcripts to complementary probes using DNA/RNA hybridization free energies, and the hybridization between partially complementary transcripts in solution using RNA/RNA free energies. The balance between these two competing reactions allows for the translation of background-subtracted intensities into transcript concentrations.
ISSN: 1471-2105
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Theoretical Physics Section
× corresponding author
# (joint) last author

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