Title: A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Authors: Bouatia-Naji, Nabila ×
Bonnefond, Amelie
Cavalcanti-Proenca, Christine
Sparso, Thomas
Holmkvist, Johan
Marchand, Marion
Delplanque, Jerome
Lobbens, Stephane
Rocheleau, Ghislain
Durand, Emmanuelle
De Graeve, Franck
Chevre, Jean-Claude
Borch-Johnsen, Knut
Hartikainen, Anna-Liisa
Ruokonen, Aimo
Tichet, Jean
Marre, Michel
Weill, Jacques
Heude, Barbara
Tauber, Maithe
Lemaire, Katleen
Schuit, Frans
Elliott, Paul
Jorgensen, Torben
Charpentier, Guillaume
Hadjadj, Samy
Cauchi, Stephane
Vaxillaire, Martine
Sladek, Robert
Visvikis-Siest, Sophie
Balkau, Beverley
Levy-Marchal, Claire
Pattou, Francois
Meyre, David
Blakemore, Alexandra I. F
Jarvelin, Marjo-Riita
Walley, Andrew J
Hansen, Torben
Dina, Christian
Pedersen, Oluf
Froguel, Philippe #
Issue Date: Jan-2009
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:41 issue:1 pages:89-94
Abstract: In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway.
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gene Expression Unit
× corresponding author
# (joint) last author

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