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Title: Evaluation of the effect of thrombolytic treatment on infarct size and left ventricular function by enzymatic, scintigraphic, and angiographic methods. The European Cooperative Study Group for Recombinant Tissue Type Plasminogen Activator
Authors: Mortelmans, Luc ×
Vanhaecke, Johan
Lesaffre, Emmanuel
Arnold, A
Urbain, J L
Hermens, W
De Roo, Michel
De Geest, H
Verstraete, Marc
Van de Werf, Frans #
Issue Date: Jun-1990
Series Title: American Heart Journal vol:119 issue:6 pages:1231-7
Abstract: In a double-blind trial of the European Cooperative Study Group, 721 patients with acute myocardial infarction of less than 5 hours' duration were given either 100 mg recombinant tissue-type plasminogen activator (rt-PA) intravenously over 3 hours or an equivalent placebo infusion. In a subset of 312 patients, infarct size was assessed by the cumulative myocardial release of alpha-hydroxybutyrate dehydrogenase (HBDH) during the first 72 hours and by planar thallium scintigraphy (index of hypoperfusion) performed 10 to 22 days after the acute event. Left ventricular ejection fraction (LVEF) was determined by contrast and nuclear angiography. The median values of HBDH during the first 72 hours were 20% lower and the median values of thallium-201 28% smaller in the rt-PA group in comparison with controls. A significant but limited improvement of angiographic LVEF (2 absolute percentage points) was also shown in the patients treated with rt-PA. A moderate but statistically significant linear association between both measurements of infarct size and LVEF was found.
ISSN: 0002-8703
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
Nuclear Medicine & Molecular Imaging
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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