The aim of this randomized, placebo-controlled study was to explore the effect of metformin in children with a neurogenic or myogenic motor deficit, who are therefore prone to develop overweight, adiposity, and insulin resistance.
Casteels K., Fieuws S., van Helvoirt M., Verpoorten C., Goemans N., Coudyzer W., Loeckx D., de Zegher F., ''Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit'', Pediatric diabetes, vol. 11, no. 1, pp. 61-69, February 2010.