Title: Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation
Authors: Thorrez, Lieven
Laudadio, Ilaria
Van Deun, Katrijn
Quintens, Roel
Hendrickx, Nico
Granvik, Mikaela
Lemaire, Katleen
Schraenen, Anica
Van Lommel, Leentje
Lehnert, Stefan
Cheng-Xue, Rui
Gilon, Patrick
Van Mechelen, Iven
Bonner-Weir, Susan
Lemaigre, Frédéric
Schuit, Frans # ×
Issue Date: Jan-2011
Publisher: Cold Spring Harbor Laboratory Press
Series Title: Genome Research vol:21 issue:1 pages:95-105
Abstract: We report on a hitherto poorly characterized class of genes that are expressed in all tissues, except in one. Often, these genes have been classified as housekeeping genes, based on their nearly ubiquitous expression. However, the specific repression in one tissue defines a special class of "disallowed genes." In this paper, we used the intersection-union test to screen for such genes in a multi-tissue panel of genome-wide mRNA expression data. We propose that disallowed genes need to be repressed in the specific target tissue to ensure correct tissue function. We provide mechanistic data of repression with two metabolic examples, exercise-induced inappropriate insulin release and interference with ketogenesis in liver. Developmentally, this repression is established during tissue maturation in the early postnatal period involving epigenetic changes in histone methylation. In addition, tissue-specific expression of microRNAs can further diminish these repressed mRNAs. Together, we provide a systematic analysis of tissue-specific repression of housekeeping genes, a phenomenon that has not been studied so far on a genome-wide basis and, when perturbed, can lead to human disease.
ISSN: 1088-9051
Publication status: published
KU Leuven publication type: IT
Appears in Collections:ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Laboratory for Cytogenetics and Genome Research
Quantitative Psychology and Individual Differences
Gene Expression Unit
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Genome Res.-2011-Thorrez-95-105.pdfMain article Published 927KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science