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Title: Drug-screening platform based on the contractility of tissue-engineered muscle
Authors: Vandenburgh, Herman ×
Shansky, Janet
Benesch-Lee, Frank
Barbata, Victoria
Reid, Jonathan
Thorrez, Lieven
Valentini, Robert
Crawford, Gregory #
Issue Date: Apr-2008
Series Title: Muscle & nerve vol:37 issue:4 pages:438-447
Abstract: A tissue-based approach to in vitro drug screening allows for determination of the cumulative positive and negative effects of a drug at the tissue rather than the cellular or subcellular level. Skeletal muscle myoblasts were tissue-engineered into three-dimensional muscle with parallel myofibers generating directed forces. When grown attached to two flexible micro-posts (mu posts) acting as artificial tendons in a 96-well plate format, the miniature bioartificial muscles (mBAMs) generated tetanic (active) forces upon electrical stimulation measured with a novel image-based motion detection system. mBAM myofiber hypertrophy and active force increased in response to insulin-like growth factor 1. In contrast, mBAM deterioration and weakness was observed with a cholesterol-lowering statin. The results described in this study demonstrate the integration of tissue engineering and biomechanical testing into a single platform for the screening of compounds affecting muscle strength.
URI: 
ISSN: 0148-639X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
× corresponding author
# (joint) last author

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