Title: Determination of grade and receptor status from the primary breast lesion by magnetic resonance spectroscopy
Authors: Lean, Cynthia
Doran, Sinead
Somorjai, Ray L.
Malycha, Peter
Clarke, David
Himmelreich, Uwe
Bourne, Roger
Dolenko, Brion
Nikulin, Alexander E.
Mountford, Carolyn # ×
Issue Date: Dec-2004
Publisher: Adenine Press
Series Title: Technology in Cancer Research and Treatment vol:3 issue:6 pages:551-556
Abstract: Magnetic resonance spectra (MRS) from fine needle aspiration biopsies (FNAB) from primary breast lesions were analysed using a pattern recognition method, Statistical Classification Strategy, to assess tumor grade and oestrogen receptor (ER) and progesterone receptor (PgR) status. Grade 1 and 2 breast cancers were separated from grade 3 cancers with a sensitivity and specificity of 96% and 95%, respectively. The ER status was predicted with a sensitivity of 91% and a specificity of 90%, and the PgR status with a sensitivity of 91% and a specificity of 86%. These classifiers provide rapid and reliable, computerized information and may offer an objective method for determining these prognostic indicators simultaneously with the diagnosis of primary pathology and lymph node involvement.
ISSN: 1533-0346
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Biomedical MRI
× corresponding author
# (joint) last author

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