Title: Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
Authors: Duque, María D ×
Camps, Pelayo
Profire, Lenuta
Montaner, Silvia
Vázquez, Santiago
Sureda, Francesc X
Mallol, Jordi
López-Querol, Marta
Naesens, Lieve
De Clercq, Erik
Prathalingam, S Radhika
Kelly, John M #
Issue Date: Apr-2009
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:17 issue:8 pages:3198-3206
Abstract: The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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