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Title: Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
Authors: Camps, Pelayo ×
Duque, María D
Vázquez, Santiago
Naesens, Lieve
De Clercq, Erik
Sureda, Francesc X
López-Querol, Marta
Camins, Antoni
Pallàs, Mercè
Prathalingam, S Radhika
Kelly, John M
Romero, Vanessa
Ivorra, Dolores
Cortés, Diego #
Issue Date: Dec-2008
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:16 issue:23 pages:9925-9936
Abstract: The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed.
URI: 
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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