Title: A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
Authors: Bouatia-Naji, Nabila ×
Rocheleau, Ghislain
Van Lommel, Leentje
Lemaire, Katleen
Schuit, Frans
Cavalcanti-Proenca, Christine
Marchand, Marion
Hartikainen, Anna-Liisa
Sovio, Ulla
De Graeve, Franck
Rung, Johan
Vaxillaire, Martine
Tichet, Jean
Marre, Michel
Balkau, Beverley
Weill, Jacques
Elliott, Paul
Jarvelin, Marjo-Riitta
Meyre, David
Polychronakos, Constantin
Dina, Christian
Sladek, Robert
Froguel, Philippe #
Issue Date: May-2008
Publisher: Amer assoc advancement science
Series Title: Science vol:320 issue:5879 pages:1085-1088
Abstract: Several studies have shown that healthy individuals with fasting plasma glucose ( FPG) levels at the high end of the normal range have an increased risk of mortality. To identify genetic determinants that contribute to interindividual variation in FPG, we tested 392,935 single- nucleotide polymorphisms ( SNPs) in 654 normoglycemic participants for association with FPG, and we replicated the most strongly associated SNP ( rs560887, P = 4 x 10(-7)) in 9353 participants. SNP rs560887 maps to intron 3 of the G6PC2 gene, which encodes glucose- 6- phosphatase catalytic subunit- related protein ( also known as IGRP), a protein selectively expressed in pancreatic islets. This SNP was associated with FPG ( linear regression coefficient beta = -0.06 millimoles per liter per A allele, combined P = 4 x 10(-23)) and with pancreatic beta cell function ( Homa-B model, combined P = 3 x 10(-13)) in three populations; however, it was not associated with type 2 diabetes risk. We speculate that G6PC2 regulates FPG by modulating the set point for glucose- stimulated insulin secretion in pancreatic beta cells.
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gene Expression Unit
× corresponding author
# (joint) last author

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