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Title: Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion
Authors: Wojciechowska, Wiktoria ×
Staessen, Jan A
Stolarz, Katarzyna
Nawrot, Tim
Filipovský, Jan
Tichá, Milena
Bianchi, Giuseppe
Brand, Eva
Cwynar, Marcin
Grodzicki, Tomasz
Kuznetsova, Tatiana
Struijker-Boudier, Harry A
Svobodová, Vlasta
Thijs, Lutgarde
Van Bortel, Luc M
Kawecka-Jaszcz, Kalina #
Issue Date: Dec-2004
Series Title: Journal of hypertension vol:22 issue:12 pages:2311-9
Abstract: OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure. In the European Project on Genes in Hypertension (EPOGH), we therefore investigated whether the ACE I/D and CYP11B2 C-344T polymorphisms influence early arterial wave reflections, a measure of vascular stiffness. METHODS: We measured the peripheral and central augmentation index of systolic blood pressure by applanation tonometry at the level of the radial artery in 622 subjects (160 families and 64 unrelated individuals) randomly recruited from three European populations, whose average urinary sodium excretion ranged from 196 to 245 mmol/day. In multivariate analyses, with sodium excretion analyzed as a continuous variable, we explored the phenotype-genotype associations by means of generalized estimating equations and the quantitative transmission disequilibrium test. RESULTS: The peripheral and central augmentation indexes were significantly higher in CYP11B2 -344C allele carriers than in -344T homozygotes. In offspring, early wave reflections increased with the transmission of the -344C allele. This effect of the CYP11B2 polymorphism occurred in subjects with a higher than median urinary sodium excretion (210 mmol/day). The ACE I/D polymorphism did not influence augmentation of systolic blood pressure. CONCLUSIONS: The CYP11B2 C-344T polymorphism affects arterial stiffness. However, sodium intake seems to modulate this genetic effect.
URI: 
ISSN: 0263-6352
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Occupational, Environmental and Insurance Medicine (-)
Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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