Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma
Miletic, Hrvoje × Fischer, Yvonne Heidemarie Giroglou, Tsanan Rueger, Maria Adele Winkeler, Alexandra Himmelreich, Uwe Stenzel, Werner Jacobs, Andreas H von Laer, Dorothee #
Association for Cancer Research
Clinical Cancer Research vol:13 issue:22 pages:6761-6768
Purpose: Lentiviral vectors pseudotyped with glycoproteins of the lymphocytic choriomeningitis virus (LCMV-GP) are promising candidates for gene therapy of malignant glioma, as they specifically and eff icefficientlytly transduce glioma cells in vitro and in vivo, Here, we evaluated the therapeutic efficacy of LCMV-GP and vesicular stornmatitis virus glycoprotein (VSV-G) pseudotyped vectors.