Title: High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model
Authors: Floris, Guiseppe ×
Debiec-Rychter, Maria
Sciot, Raphael
Stefan, Cristiana
Fieuws, Steffen
Machiels, Kathleen
Atadja, Peter
Wozniak, Agnieszka
Faa, Gavino
Schöffski, Patrick #
Issue Date: 15-Jun-2009
Publisher: Amer assoc cancer research
Series Title: Clinical Cancer Research vol:15 issue:12 pages:4066-4076
Abstract: Purpose: Histone deacetylase inhibitors have emerged as potent anticancer compounds. Using a nude-mouse xenograft model, for the first time we evaluated the response of human gastrointestinal stromal tumors (GIST) carrying different oncogenic KIT mutations to panobinostat (LBH589), administered single or in combination with imatinib.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
Department of Human Genetics - miscellaneous
Translational Cell & Tissue Research
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
Laboratory for Genetics of Malignant Disorders
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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