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Title: Hepatosplenic gamma delta T-Cell Lymphoma After Liver Transplantation: Report of the First 2 Cases and Review of the Literature
Authors: Roelandt, Philip
Maertens, Johan
Vandenberghe, Peter
Verslype, Chris
Roskams, Tania
Aerts, Raymond
Nevens, Frederik
Dierickx, Daan # ×
Issue Date: Jul-2009
Publisher: Wiley & Sons
Series Title: Liver Transplantation vol:15 issue:7 pages:686-692
Abstract: Hepatosplenic gamma delta T-cell lymphoma is a rare lymphoproliferative disorder originating from natural killer-like V delta 1-lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic gamma delta-lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed. Liver Transpl 15: 686-692, 2009. (C) 2009 AASLD.
URI: 
ISSN: 1527-6465
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Hepatology
Translational Cell & Tissue Research
Hematology Section (-)
Abdominal Surgical Oncology
Clinical Genetics Section (-)
× corresponding author
# (joint) last author

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