Title: Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice
Authors: Moens, Leen
Jeurissen, Axel
Nierkens, Stefan
Boon, Louis
Van Kaer, Luc
Kasran, Ahmad
Wuyts, Greet
Ceuppens, Jan
Bossuyt, Xavier # ×
Issue Date: May-2009
Publisher: American Society for Microbiology (ASM)
Series Title: Infection and Immunity vol:77 issue:5 pages:1976-1980
Abstract: Streptococcus pneumoniae is a bacterial microorganism that frequently causes serious infection, particularly in children and the elderly. Protection against infection with S. pneumoniae is based mainly on the generation of antibodies to the pneumococcal capsular polysaccharides (caps-PS), but the mechanisms responsible for the generation of anticapsular antibodies remain incompletely understood. The aim of the present study was to evaluate the role of CD1-restricted T cells in the antibody response to caps-PS. When immunized with Pneumo23, wild-type mice and CD1 knockout mice on BALB/c and C57BL/6 backgrounds generated immunoglobulin M (IgM) and IgG antibody responses to soluble caps-PS that were comparable. Similar results were obtained after immunization with heat-inactivated S. pneumoniae. The IgM and IgG antibody response of wild-type mice to Pneumo23 was not affected by an antagonizing monoclonal anti-CD1 antibody treatment. In summary, our data provide evidence that the antibody response to caps-PS is generated independently of CD1 expression.
ISSN: 0019-9567
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Immunology
Laboratory of Clinical Bacteriology and Mycology
Experimental Laboratory Immunology
× corresponding author
# (joint) last author

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