Author:

Keywords:

Administration, Oral, Angina, Unstable, Antibodies, Monoclonal, C-Reactive Protein, Diagnosis, Differential, Enoxaparin, Government Agencies, Heparin, Low-Molecular-Weight, Humans, Immunoglobulin Fab Fragments, Infusions, Intravenous, Myocardial Infarction, National Institutes of Health (U.S.), Peptides, Platelet Aggregation Inhibitors, Platelet Glycoprotein GPIIb-IIIa Complex, Practice Guidelines, Risk, Time Factors, Troponin I, Troponin T, Tyrosine, United States, Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, ACUTE CORONARY SYNDROMES, C-REACTIVE PROTEIN, CARDIAC TROPONIN-T, GLYCOPROTEIN IIB/IIIA ANTAGONIST, ACUTE MYOCARDIAL-INFARCTION, MOLECULAR-WEIGHT HEPARIN, ARTERY DISEASE, PROGNOSTIC VALUE, RISK STRATIFICATION, CLINICAL PRESENTATION, Abciximab, Eptifibatide, Practice Guidelines as Topic, Tirofiban, 11 Medical and Health Sciences, 32 Biomedical and clinical sciences, 42 Health sciences

Abstract:

In 1994, the Agency for Health Care Policy and Research sponsored the development of guidelines for diagnosing and managing patients with unstable angina. Since their publication, several important developments have occurred. The prognostic value of biochemical assays for cardiac-specific troponins T and I have been shown in many studies. The possible role for C-reactive protein in determining prognosis deserves further investigation. Substantial clinical benefits have been obtained with intravenous inhibitors of the platelet glycoprotein (GP) IIb-IIIa receptor (abciximab, eptifibatide, tirofiban) and with one of the low-molecular-weight heparins (enoxaparin). The therapeutic potential of other low-molecular-weight heparins, direct thrombin inhibitors, and oral GP IIb-IIIa inhibitors remains to be clarified. On the basis of this evidence, consideration should be given to measuring serum levels of a cardiac troponin (either T or I) and using intravenous GP IIb-IIIa inhibitors and low-molecular-weight heparin in the standard management of patients with unstable angina.