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Title: Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt
Authors: Remijsen, Quinten
Berghe, Tom Vanden
Parthoens, Eef
Asselbergh, Bob
Vandenabeele, Peter
Willems, Jean # ×
Issue Date: Mar-2009
Publisher: Federation amer soc exp biol
Series Title: Journal of leukocyte biology vol:85 issue:3 pages:497-507
Abstract: Neutrophil cell death plays a crucial role in neutrophil homeostasis and the resolution of inflammation. The superoxide-producing NADPH oxidase is involved in pathogen degradation and subsequent activation of cell death programs. Neutrophils from patients with chronic granulomatous disease, who have a deficient NADPH oxidase activity, have been demonstrated previously to have a prolonged lifespan, suggesting that a basal NADPH oxidase activity also regulates spontaneous neutrophil turnover. The NADPH oxidase inhibitor parabutoporin (PP) does delay spontaneous apoptosis, but this effect is completely independent of NADPH oxidase inhibition. Instead, the prosurvival effect of PP depends on activation of protein kinase B/Akt via lipid raft signaling. Disruption of lipid rafts abrogates the prosurvival effect without interfering with NADPH oxidase activity. Furthermore, we cannot detect a different rate of spontaneous apoptosis between normal and NADPH oxidase-deficient neutrophils, arguing against a role of NADPH oxidase in spontaneous neutrophil apoptosis. J. Leukoc. Biol. 85: 497-507; 2009.
ISSN: 0741-5400
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
Microbiology and Immunology, Campus Kulak Kortrijk
Department of Microbiology & Immunology - miscellaneous
× corresponding author
# (joint) last author

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