Title: Characterization of myocardial infarction as an end point in two large trials of acute coronary syndromes
Authors: Mahaffey, Kenneth W ×
Roe, Matthew T
Kilaru, Rakhi
French, John K
Alexander, John H
Berdan, Lisa G
Van de Werf, Frans
Simoons, Maarten L
Weaver, W Douglas
White, Harvey D
Lincoff, A Michael
Kleiman, Neal S
Topol, Eric J
Harrington, Robert A #
Issue Date: Jun-2005
Series Title: The American journal of cardiology vol:95 issue:12 pages:1404-8
Abstract: Myocardial infarction (MI) is a key component of composite end points in trials that evaluate new therapies in non-ST-segment elevation acute coronary syndromes. Types of MI events in these trials have not been well characterized. A similar clinical-events classification process adjudicated all suspected MI end points in the PURSUIT and PARAGON B trials. All MI end points were classified as nonprocedural, related to percutaneous coronary intervention, or related to coronary artery bypass grafting. A total of 16,173 patients was enrolled in the 2 trials, and 1,802 MI end points occurred during a 30-day follow-up. Nearly 66% of MI end points were not related to percutaneous coronary intervention or coronary artery bypass grafting. Patients who had MI compared with those who did not had higher 30-day mortality rates (13.6% vs 2.3%, p <0.001) and 6-month mortality rates (18.4% vs 4.4%, p <0.001). Patients who had been randomized to glycoprotein IIb/IIIa inhibition showed trends toward fewer MI events regardless of type. Two-thirds of MI end points in 2 large trials of acute coronary syndrome were not related to procedure. All MI types were associated with worse short- and long-term outcomes. Characterization of the type of MI provides an opportunity for more informed interpretation of clinical trial results and improved planning for future trials.
ISSN: 0002-9149
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
× corresponding author
# (joint) last author

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