Title: Efficient stem cell labeling for MRI studies
Authors: Kuestermann, E *
Himmelreich, Uwe * ×
Kandal, K
Geelen, T
Ketkar, A
Wiedermann, D
Strecker, C
Esser, J
Arnhold, S
Hoehn, M #
Issue Date: Jan-2008
Publisher: John Wiley & Sons Ltd.
Series Title: Contrast Media & Molecular Imaging vol:3 issue:1 pages:27-37
Abstract: Iron oxide particles are especially suited for cell tracking experiments due to their extraordinarily molar relaxivity as compared with other paramagnetic nuclei. We have compared different iron oxide particles (Sinerem, Endorem and magnetic microspheres) for their suitability to label embryonic stem cells (D3 cell line). In addition to detectability thresholds, particular attention has been paid to the evaluation of long-term stability of the labelling procedure (up to 4 weeks) as well as to toxic and other adverse effects on cell viability. Comparative studies were performed using neural progenitor cells (C17.2) and dendritic cells. The present study indicates strong dependence of the label efficiency and stability on the iron oxide particles and cell lines in use. Copyright (c) 2008 John Wiley & Sons, Ltd.
ISSN: 1555-4309
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Biomedical MRI
* (joint) first author
× corresponding author
# (joint) last author

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