Title: Targeted disruption of the mouse Lipoma Preferred Partner gene
Authors: Vervenne, Hilke
Crombez, Koen
Delvaux, Els
Janssens, Veerle
Van de Ven, Willem
Petit, Marleen # ×
Issue Date: Feb-2009
Publisher: Academic Press
Series Title: Biochemical and Biophysical Research Communications vol:379 issue:2 pages:368-373
Abstract: LPP (Lipoma Preferred Partner) is a zyxin-related cell adhesion protein that is involved in the regulation of cell migration. We generated mice with a targeted disruption of the Lpp gene and analysed the importance of Lpp for embryonic development and adult functions. Aberrant Mendelian inheritance in heterozygous crosses suggested partial embryonic lethality of Lpp(-/-) females. Fertility of Lpp(-/-) males was proven to be normal, however, females from Lpp(-/-) x Lpp(-/-) crosses produced a strongly reduced number of offspring, probably due to a combination of female embryonic lethality and aberrant pregnancies. Apart from these developmental and reproductive abnormalities, Lpp(-/-) mice that were born reached adulthood without displaying any additional macroscopic defects. On the other hand, Lpp(-/-) mouse embryonic fibroblasts exhibited reduced migration capacity, reduced viability, and reduced expression of some Lpp interaction partners. Finally, we discovered a short nuclear form of Lpp, expressed mainly in testis via an alternative promoter.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Protein Phosphorylation and Proteomics
Laboratory for Intensive Care Medicine (-)
Department of Human Genetics - miscellaneous
Laboratory of Molecular Oncology (-)
× corresponding author
# (joint) last author

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