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Title: Synthetic and biogenic magnetic nanoparticles for tracking of stem cells and dendritic cells
Authors: Schwarz, Sebastian
Fernandes, Fabiana
Sanroman, Laura
Hodenius, Michael
Lang, Claus
Himmelreich, Uwe
Schmitz-Rode, Thomas
Schueler, Dirk
Hoehn, Mathias
Zenke, Martin
Hieronymus, Thomas # ×
Issue Date: May-2009
Publisher: North-Holland Pub. Co.
Series Title: Journal of Magnetism and Magnetic Materials vol:321 issue:10 pages:1533-1538
Abstract: Accurate delivery of cells to target organs is critical for success of cell-based therapies with stem cells or
immune cells such as antigen-presenting dendritic cells (DC). Labeling with contrast agents before
implantation provides a powerful means for monitoring cellular migration using magnetic resonance
imaging (MRI). In this study, we investigated the uptake of fully synthesized or bacterial magnetic
nanoparticles (MNPs) into hematopoietic Flt3+ stem cells and DC from mouse bone marrow. We show
that (i) uptake of both synthetic and biogenic nanoparticles into cells endow magnetic activity and
(ii) low numbers of MNP-loaded cells are readily detected by MRI.
2009 Elsevier B.V. All rights reserved.
ISSN: 0304-8853
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Biomedical MRI
× corresponding author
# (joint) last author

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