Title: Effect of chronic diuretic treatment on the plasma renin-angiotensin-aldosterone system in essential hypertension
Authors: Lijnen, Paul ×
Fagard, Robert
Staessen, Jan A
Amery, A #
Issue Date: Sep-1981
Series Title: British journal of clinical pharmacology vol:12 issue:3 pages:387-92
Abstract: 1 Chronic treatment with a constant dose of hydrochlorothiazide or tienilic acid increases plasma renin activity (PRA) acutely to reach a maximum within the first week. 2 During chronic diuretic therapy from 1 month to 1 year, PRA remained elevated at a rather constant level, though this was somewhat lower than the maximum level reached after 1 week. 3 A significant (P less than 0.01) correlation (r = 0.74) between changes in plasma angiotensin II and renin activity provoked by chronic treatment for 3 months with hydrochlorothiazide and tienilic acid was found. 4 The increase in plasma aldosterone during chronic treatment with hydrochlorothiazide and tienilic acid (1000 mg) is related (r = 0.68; P less than 0.01) to the rise in plasma angiotensin II.
ISSN: 0306-5251
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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