Title: Refractory thrombocytopenia due to anti-PLA1 antibodies following autologous peripheral blood stem cell transplantation: case report and review of literature
Authors: Roy, V ×
Verfaillie, Catherine #
Issue Date: Jan-1996
Series Title: Bone marrow transplantation vol:17 issue:1 pages:115-7
Abstract: A 43-year-old woman developed life-threatening refractory thrombocytopenia following autologous peripheral blood stem cell transplantation for metastatic breast carcinoma. Anti-PLA1 antibodies were demonstrated in the patient's plasma. Treatment with intravenous immunoglobulin and transfusion of PLA1-negative blood products restored platelet responsiveness. PLA1 allo-antibodies should be considered as a possible cause of severe refractory thrombocytopenia in marrow transplant patients. It is important to make this diagnosis as the mainstay of treatment is the avoidance of blood products from PLA1-positive donors (98% of the population).
ISSN: 0268-3369
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdepartemental Stem Cell Institute (-)
× corresponding author
# (joint) last author

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