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Title: In vitro effect of xipamide on sodium-potassium transport systems in human erythrocytes
Authors: Lijnen, Paul ×
Fagard, Robert
Staessen, Jan A
Amery, A #
Issue Date: Aug-1988
Series Title: Methods and findings in experimental and clinical pharmacology vol:10 issue:8 pages:527-30
Abstract: The in vitro effects of xipamide in a concentration range of 10(-8) to 10(-2) M were investigated on various Na+ and K+ transport systems in human red blood cells. Xipamide inhibited the anion carrier or DIDS-sensitive LiCO3- -influx starting from a concentration of 10(-5) M. However, a decrease in the Na+, K+-pump and the Na+, K+-cotransport activity and a rise in the passive permeability of the cell membrane was only observed starting from a concentration of 10(-4) M xipamide.
ISSN: 0379-0355
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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