Title: Fibrinolysis-independent role of plasmin and its activators in the hematopoietic recovery after myeloablation
Authors: Tjwa, Marc ×
Moura, Rute
Moons, Lieve
Plaisance, Stephane
De Mol, Maria
Jansen, Sandra
Dewerchin, Mieke
Verfaillie, Catherine
Carmeliet, Peter #
Issue Date: Nov-2009
Publisher: Wiley-Blackwell Publishing Ltd.
Series Title: Journal of Cellular and Molecular Medicine vol:13 issue:11-12 pages:4587-4595
Abstract: Proteinases have been implicated in the mobilization of hematopoietic progenitor cells (HPCs) from the bone marrow (BM). Here, we report the involvement of the plasminogen (Plg) system in the hematopoietic recovery following chemotherapy. By using gene deficient mice, we found that plasmin and its activators tPA and uPA play a role in the hematopoietic recovery upon delivery of the cytotoxic agent 5-fluoro-uracil (5-FU). The impaired hematopoietic recovery of Plg deficient (Plg(-/-)) mice after 5-FU was not rescued by depletion of fibrinogen, indicating that it was not due to defective fibrinolysis. Instead, loss of Plg impaired breakdown of fibronectin, VCAM-1 and laminin, BM matrix proteins involved in adhesion of HPCs to their BM microenvironment and in transendothelial migration of HPCs. These findings provide novel insights in how plasmin regulates hematopoietic recovery upon cytotoxic myeloablation.
ISSN: 1582-4934
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdepartemental Stem Cell Institute (-)
Vesalius Research Centre (-)
Animal Physiology and Neurobiology Section - miscellaneous
Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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