Title: Synthesis and fungicidal activity of 3,5-dichloropyrazin-2(1H)-one derivatives
Authors: Fran├žois, Isabelle
Cammue, Bruno
Bresseleers, Sara
Fleuren, Hein
Hoornaert, Georges
Mehta Pravinchandra, Vaibhav
Modha, Sachinkumar
Van der Eycken, Erik
Thevissen, Karin # ×
Issue Date: Aug-2009
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:19 issue:15 pages:4064-6
Abstract: We synthesized a family of 3,5-dichloropyrazin-2(1H)-one derivatives and assessed their in vitro fungicidal activity against Candida albicans. Compounds 11 and 20 were most active against C. albicans and induced accumulation of reactive oxygen species in this pathogen. Using a genome-wide approach in the yeast Saccharomyces cerevisiae, we demonstrated that genes involved in vacuolar functionality and DNA-related functions play an important role in cellular mechanisms underlying the fungicidal activity of these compounds.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Chemistry - miscellaneous
Molecular Design and Synthesis
Centre of Microbial and Plant Genetics
× corresponding author
# (joint) last author

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