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Title: Coronary thrombolysis with recombinant tissue-type plasminogen activator: patency rate and regional wall motion after 3 months
Authors: Jang, I K ×
Vanhaecke, Johan
de Geest, H
Verstraete, Marc
Collen, Desire
Van de Werf, Frans #
Issue Date: Dec-1986
Series Title: Journal of the American College of Cardiology vol:8 issue:6 pages:1455-60
Abstract: In a double-blind, placebo-controlled, randomized trial the long-term (+/- 3 months) effects of intravenous administration of recombinant tissue-type plasminogen activator (rt-PA) versus placebo were compared in relation to left ventricular function, coronary patency rate and antigenicity in 28 patients with a first myocardial infarction. Patency rate of the infarct-related coronary artery at the end of the rt-PA/placebo infusion and after 3 months of medical treatment (including oral anticoagulant agents) was 86 and 71%, respectively, in the rt-PA group, and 21 and 58%, respectively, in the placebo group. Regional wall motion of the infarct-related area was quantitated with digital subtraction angiography. Intrapatient comparisons revealed significant improvement in regional wall motion after 3 months in both the rt-PA and placebo groups. The improvement in the rt-PA group was not significantly greater than that in the placebo group. Thirteen patients (10 with rt-PA and 3 with placebo) with persistent patency (both early and late) of the infarct-related coronary artery showed a significant improvement of both global and regional left ventricular function, while 8 patients (2 with rt-PA and 6 with placebo) with persistent occlusion showed no changes. Antibodies against rt-PA were not detected in serum 2 weeks after the infusion, which is indicative of the lack of antigenicity of rt-PA and allows for its repeated administration.
ISSN: 0735-1097
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
Faculty of Medicine - miscellaneous
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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