Title: Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
Authors: Paraskevis, Dimitrios ×
Pybus, Oliver
Magiorkinis, Gkikas
Hatzakis, Angelos
Wensing, Annemarie
van de Vijver, David
Albert, Jan
Angarano, Guiseppe
Asjo, Birgitta
Balotta, Claudia
Boeri, Enzo
Camacho, Ricardo
Chaix, Marie-Laure
Coughlan, Suzie
Costagliola, Dominique
De Luca, Andrea
de Mendoza, Carlos
Derdelinckx, Inge
Grossman, Zehava
Hamouda, Osama
Hoepelman, I
Horban, Andrzej
Korn, Klaus
Kuecherer, Claudia
Leitner, Thomas
Loveday, Clive
Macrae, Eilidh
Maljkovic, I
Meyer, Laurence
Nielsen, Claus
Op de Coul, Eline
Ormaasen, Vidar
Perrin, Luc
Puchhammer-Stockl, Elisabeth
Ruiz, Lidia
Salminen, Mika
Schmit, Jean-Claude
Schuurman, Rob
Soriano, Vincent
Stanczak, J
Stanojevic, Maja
Struck, Daniel
Van Laethem, Kristel
Violin, M
Yerly, Sabine
Zazzi, Maurizio
Boucher, Charles
Vandamme, Anne-Mieke
Programme Spread #
Issue Date: May-2009
Series Title: Retrovirology vol:6 issue:1 pages:49
Article number: 49
Abstract: ABSTRACT: BACKGROUND: The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced. RESULTS: In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferred from viral phylogenies by character reconstruction using parsimony. With regard to the spatial dispersal of the HIV subtype B sequences across viral phylogenies, in most of the countries in Europe the epidemic was introduced by multiple sources and subsequently spread within local networks. Poland provides an exception where most of the infections were the result of a single point introduction. According to the significant migratory pathways, we show that there are considerable differences across Europe. Specifically, Greece, Portugal, Serbia and Spain, provide sources shedding HIV-1; Austria, Belgium and Luxembourg, on the other hand, are migratory targets, while for Denmark, Germany, Italy, Israel, Norway, the Netherlands, Sweden, Switzerland and the UK we inferred significant bidirectional migration. For Poland no significant migratory pathways were inferred. CONCLUSIONS: Subtype B phylogeographies provide a new insight about the geographical distribution of viral lineages, as well as the significant pathways of virus dispersal across Europe, suggesting that intervention strategies should also address tourists, travellers and migrants.
ISSN: 1742-4690
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Laboratory for Clinical Infectious and Inflammatory Disorders
× corresponding author
# (joint) last author

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