Title: Human immunodeficiency virus type 1 escape from cyclotriazadisulfonamide-induced CD4-targeted entry inhibition is associated with increased neutralizing antibody susceptibility
Authors: Vermeire, Kurt ×
Van Laethem, Kristel
Janssens, Wouter
Bell, Thomas W
Schols, Dominique #
Issue Date: Sep-2009
Publisher: American Society for Microbiology (ASM)
Series Title: Journal of Virology vol:83 issue:18 pages:9577-9583
Abstract: Continuous specific downmodulation of CD4 receptor expression in T-lymphocytes by the small molecule cyclotriazadisulfonamide (CADA) selected for CADA-resistant HIV-1NL4.3 virus containing unique mutations in the C4 and V5 regions of gp120, likely stabilizing the CD4 binding conformation. The amino acid changes in Env were associated with decreased susceptibility to anti-CD4 mAb treatment of the cells, and with higher susceptibility of the virus to sCD4. In addition, the acquired ability of CADA-resistant virus to infect cells with low CD4 expression was associated with increased susceptibility of the virus to neutralizing antibodies from sera of several HIV-1 infected patients.
ISSN: 0022-538X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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