Title: VEGF protects motor neurons against excitotoxicity by upregulation of GluR2
Authors: Bogaert, Elke ×
Van Damme, Philip
Poesen, Koen
Dhondt, Joke
Hersmus, Nicole
Kiraly, Dora
Scheveneels, Wendy
Robberecht, Wim
Van Den Bosch, Ludo #
Issue Date: Dec-2010
Publisher: Elsevier
Series Title: Neurobiology of Aging vol:31 issue:12 pages:2185-2191
Abstract: Influx of Ca(2+) ions through the alpha-amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptors is toxic to neurons and contributes to motor neuron degeneration observed in amyotrophic lateral sclerosis (ALS). The Ca(2+) permeability of the AMPA receptor depends on its subunit composition. If the GluR2 subunit is present in the receptor complex, the AMPA receptor is impermeable to Ca(2+). In this study, we identified vascular endothelial growth factor-A (VEGF) as a GluR2 inducing molecule. Cultured motor neurons pretreated with VEGF displayed higher GluR2 levels. This resulted in AMPA receptor currents with a low relative Ca(2+) permeability and in motor neurons that were less vulnerable to AMPA receptor-mediated excitotoxicity. This effect of VEGF was mediated through the VEGFR2 present on the motor neurons and was due to stimulation of GluR2 transcription. Intracerebroventricular treatment with VEGF similarly induced GluR2 expression in the ventral spinal cord of rats and this mechanism contributes to the protective effect of VEGF on motor neurons.
ISSN: 0197-4580
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Vesalius Research Centre (-)
Laboratory for Neurobiology
× corresponding author
# (joint) last author

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