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Title: The genome of the kinetoplastid parasite, Leishmania major
Authors: Ivens, AC ×
Peacock, CS
Worthey, EA
Murphy, L
Aggarwal, G
Berriman, M
Sisk, E
Rajandream, MA
Adlem, E
Aert, Rita
Anupama, A
Myler, PJ
Apostolou, Z
Attipoe, P
Bason, N
Bauser, C
Beck, A
Beverley, SM
Bianchettin, G
Borzym, K
Bothe, G
Bruschi, CV
Collins, M
Cadag, E
Ciarloni, L
Clayton, C
Coulson, RMR
Cronin, A
Cruz, AK
Davies, RM
De Gaudenzi, J
Dobson, DE
Duesterhoeft, A
Fazelina, G
Fosker, N
Frasch, AC
Fraser, A
Fuchs, M
Gabel, C
Goble, A
Goffeau, A
Harris, D
Hertz-Fowler, C
Hilbert, H
Horn, D
Huang, YT
Klages, S
Knights, A
Kube, M
Larke, N
Litvin, L
Lord, A
Louie, T
Marra, M
Masuy, D
Matthews, K
Michaeli, S
Mottram, JC
Muller-Auer, S
Munden, H
Nelson, S
Norbertczak, H
Oliver, K
O'Neil, S
Pentony, M
Pohl, TM
Price, C
Purnelle, B
Quail, MA
Rabbinowitsch, E
Reinhardt, R
Rieger, M
Rinta, J
Robben, Johan
Robertson, L
Ruiz, JC
Rutter, S
Saunders, D
Schafer, M
Schein, J
Schwartz, DC
Seeger, K
Seyler, A
Sharp, S
Shin, H
Sivam, D
Squares, R
Squares, S
Tosato, V
Vogt, C
Volckaert, Guido
Wambutt, R
Warren, T
Wedler, H
Woodward, J
Zhou, SG
Zimmermann, W
Smith, DF
Blackwell, JM
Stuart, KD
Barrell, B #
Issue Date: 15-Jul-2005
Publisher: Amer assoc advancement science
Series Title: Science vol:309 issue:5733 pages:436-442
Abstract: Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.
URI: 
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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