Title: Response of the systemic pulmonary circulation to labetalol at rest and during exercise
Authors: Fagard, Robert ×
Lijnen, Paul
Amery, A #
Issue Date: Jun-1982
Series Title: British journal of clinical pharmacology vol:13 issue:1 Suppl pages:13S-17S
Abstract: 1 Labetalol was administered to 18 hypertensive patients for an average duration of 2.44 weeks, with an average final daily dose of 1.65 g (principally to study its short-term haemodynamic effects). 2 Labetalol decreased resting heart rate by 16% and maximal exercise heart rate by 21%; the phenylephrine-induced increase in systolic brachial arterial pressure was reduced by 36%. 3 During labetalol treatment brachial arterial pressure was decreased by 29/15 mmHg in the recumbent position, by 41/23 mmHg at rest sitting and by 53/23 mmHg at maximal exercise; total peripheral resistance was not significantly affected at rest recumbent but was reduced at sitting and at exercise; cardiac output was decreased in all conditions. 4 Labetalol reduced mean pulmonary arterial and capillary wedge pressures only in the sitting position. Pulmonary vascular resistance remained unchanged. 5 The drug produced significant decreases in plasma renin activity and in plasma aldosterone concentration.
ISSN: 0306-5251
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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