Title: Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors
Authors: Breugelmans, Bert ×
Simonet, Gert
van Hoef, Vincent
Van Soest, Sofie
Vanden Broeck, Jozef #
Issue Date: Mar-2009
Publisher: Elsevier science inc
Series Title: Peptides vol:30 issue:3 pages:622-632
Abstract: Members of the pacifastin family are serine peptidase inhibitors, found in arthropods and have many members within different insect orders. Based on their structural characteristics, inhibitors of this peptide family are divided into two groups (I and II). Members of both groups exhibit specificity towards different types of serine peptidases. In addition, group I inhibitors display species selectivity. The specificity and selectivity of these inhibitors depends on the nature of their P1 residue and on additional interaction sites at the inhibitor's surface. Functional analysis studies have shown that crustacean pacifastin plays a key role in the immune response, whereas insect pacifastin-like peptides have multiple regulatory functions in processes involved in immunity, reproduction, phase transition, etc. (c) 2008 Elsevier Inc. All rights reserved.
ISSN: 0196-9781
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Experimental Cardiology
× corresponding author
# (joint) last author

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