Title: Microbial interactions influence inflammatory host cell responses
Authors: Sliepen, Isabelle
Van Damme, Jozef
Van Essche, Mark
Loozen, Gitte
Quirynen, Marc
Teughels, Wim # ×
Issue Date: Nov-2009
Publisher: Journal of Dental Research
Series Title: Journal of Dental Research vol:88 issue:11 pages:1026-1030
Abstract: The inflammatory response plays an important role in the tissue destruction associated with periodontitis. Bacterial species can regulate the inflammatory response of host cells, triggered by pathogens. It was hypothesized that also in the field of oral microbiology/immunology such effects of bacterial interactions on inflammatory host cell responses might be present. In this study the effect of beneficial, commensal and pathogenic species on Aggregatibacter actinomycetemcomitans-induced interleukin-8 (IL-8) production by human cells was investigated.
The beneficial species, Streptococcus mitis, Streptococcus salivarius and Streptococcus sanguinis, were able to lower the IL-8 production triggered by A. actinomycetemcomitans. The inhibitory effect was also achieved by the application of streptococcal supernatants. In contrast, the commensal Streptococcus gordonii caused no reduction, and the pathogen Fusobacterium nucleatum increased the IL-8 production by the host cells.
These results show that bacterial species can influence the inflammatory response of host cells triggered by infection with A. actinomycetemcomitans.
ISSN: 0022-0345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Periodontology
Faculty of Medicine - miscellaneous
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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