Title: The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward
Authors: Ortibus, Els ×
Lopriore, Enrico
Deprest, Jan
Vandenbussche, Frank P
Walther, Frans J
Diemert, Anke
Hecher, Kurt
Lagae, Lieven
De Cock, Paul
Lewi, Paul
Lewi, Liesbeth #
Issue Date: May-2009
Publisher: Mosby-elsevier
Series Title: American Journal of Obstetrics and Gynecology vol:200 issue:5 pages:494.e1-8
Conference: 29th Annual Scientific Meeting of the Society for Maternal-Fetal Medicine edition:29th location:San Diego, CA date:26-31 Jan. 2009
Abstract: OBJECTIVES: We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment. STUDY DESIGN: We conducted a prospective cohort study of 136 monochorionic twins followed up from the first trimester until infancy. RESULTS: A total of 122 (90%) pregnancies resulted in 2 survivors, 6 (4%) in 1 survivor and 8 (6%) in no survivor. In all, 230 (92%) of 250 surviving infants were assessed at a mean age of 24 months. Neurodevelopmental impairment was present in 22 (10%) infants. Death or impairment of 1 or both infants occurred in 28 (22%) of 126 pregnancies. Twin-to-twin transfusion syndrome and assisted conception increased the risk of both death and impairment, whereas early-onset discordant growth only increased the risk of death. CONCLUSION: The mortality in this prospective series was 8% and neurodevelopmental impairment occurred in 10% of infants.
ISSN: 0002-9378
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Foetal Medicine Section (-)
Section Child - Miscellaneous (-)
Brain & Metabolism Section (-)
Section Woman - Miscellaneous (-)
Youth Health (-)
× corresponding author
# (joint) last author

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