Title: Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice
Authors: Pokreisz, Peter ×
Vandenwijngaert, Sara
Bito, Virginie
Van den Bergh, Aldegonda
Lenaerts, Ilse
Busch, Cornelius
Marsboom, Glenn
Gheysens, Olivier
Vermeersch, Pieter
Biesmans, Liesbeth
Liu, Xiaoshun
Gillijns, Hilde
Pellens, Marijke
Van Lommel, Alfons
Buys, Emmanuel
Schoonjans, Luc
Vanhaecke, Johan
Verbeken, Eric
Sipido, Karin
Herijgers, Paul
Bloch, Kenneth D
Janssens, Stefan #
Issue Date: Jan-2009
Publisher: Lippincott Williams & Wilkins
Series Title: Circulation vol:119 issue:3 pages:408-416
Abstract: Background-Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP catabolism, is increased in human right ventricular hypertrophy, but its role in left ventricular (LV) failure remains incompletely understood. We therefore measured LV PDE5 expression in patients with advanced systolic heart failure and characterized LV remodeling after myocardial infarction in transgenic mice with cardiomyocyte-specific overexpression of PDE5 (PDE5-TG).
ISSN: 0009-7322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Experimental Cardiac Surgery (-)
Translational Cell & Tissue Research
Experimental Cardiology
Vesalius Research Centre (-)
Laboratory of Clinical Bacteriology and Mycology
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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