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Title: Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation - Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells
Authors: Saliez, J
Bouzin, C
Rath, G
Ghisdal, P
Desjardins, F
Rezzani, R
Rodella, L. F
Vriens, Joris
Nilius, Bernd
Feron, O
Balligand, J-L
Dessy, C # ×
Issue Date: Feb-2008
Publisher: Lippincott williams & wilkins
Series Title: Circulation vol:117 issue:8 pages:1065-1074
Abstract: Background- In endothelial cells, caveolin-1, the structural protein of caveolae, acts as a scaffolding protein to cluster lipids and signaling molecules within caveolae and, in some instances, regulates the activity of proteins targeted to caveolae. Specifically, different putative mediators of the endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation are located in caveolae and/or regulated by the structural protein caveolin-1, such as potassium channels, calcium regulatory proteins, and connexin 43, a molecular component of gap junctions.
URI: 
ISSN: 0009-7322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Ion Channel Research
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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