Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation - Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells
Saliez, J Bouzin, C Rath, G Ghisdal, P Desjardins, F Rezzani, R Rodella, L. F Vriens, Joris Nilius, Bernd Feron, O Balligand, J-L Dessy, C # ×
Lippincott williams & wilkins
Circulation vol:117 issue:8 pages:1065-1074
Background- In endothelial cells, caveolin-1, the structural protein of caveolae, acts as a scaffolding protein to cluster lipids and signaling molecules within caveolae and, in some instances, regulates the activity of proteins targeted to caveolae. Specifically, different putative mediators of the endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation are located in caveolae and/or regulated by the structural protein caveolin-1, such as potassium channels, calcium regulatory proteins, and connexin 43, a molecular component of gap junctions.