Title: Synthesis and modifications of a small library of 1,4-benzodiazepin-3-ones toward potential inhibitors of the collagen-von Willebrand Factor interaction
Authors: Deschrijver, Tiny
Verwilst, Peter
Broos, Katleen
Deckmyn, Hans
Dehaen, Wim
De Borggraeve, Wim # ×
Issue Date: Jun-2009
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:65 issue:23 pages:4521-4529
Abstract: A library of 1,4-benzodiazepin-3-one-based turn mimetics were synthesized and tested for their antithrombotic abilities. These mimetics are designed to incorporate amino acid side chains of the previously reported paratope of the inhibitory anti-von Willebrand Factor antibody 82D6A3. Modifications were performed oil the scaffolds by alkylation of the N-1-position and acylation of the reduced nitro group. Hereby the number of functional groups incorporated oil the core was expanded. (C) 2009 Elsevier Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Chemistry, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Molecular Design and Synthesis
× corresponding author
# (joint) last author

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