Title: Glycaemic control and perioperative organ protection
Authors: Berkers, Joost *
Gunst, Jan *
Vanhorebeek, Ilse
Van den Berghe, Greet # ×
Issue Date: Mar-2008
Publisher: Bailliere Tindall
Series Title: Best Practice & Research. Clinical Anaesthesiology vol:22 issue:1 pages:135-149
Abstract: The concept of stress hyperglycaemia as an adaptive, beneficial response in critical illness has recently been challenged. Two large prospective randomized controlled trials in the Leuven University Hospital surgical and medical ICUs demonstrated that maintenance of normoglycaemia with intensive insulin therapy substantially prevents morbidity and reduces mortality. Strict normoglycaemia is required to gain most clinical benefit. With this therapy the risk of hypoglycaemia increased, but without inducing obvious clinical sequellae. Other studies have been used to advocate against implementation of intensive insulin therapy by showing lack of benefit or questioning safety. However, these studies are inconclusive on this subject, due to problems of not reaching normal glucose levels clearly separated from the standard glycaemic group or lack of statistical power. Clearly, future studies should be adequately powered and comply with the study protocol in order to confirm the survival and other clinical benefits of intensive insulin therapy.
ISSN: 1753-3740
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Intensive Care Medicine (-)
Laboratory of Intensive Care Medicine
* (joint) first author
× corresponding author
# (joint) last author

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