Title: Synthesis and biological evaluation of carbon-11-and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging
Authors: Evens, Nele ×
Muccioli, Giulio G
Houbrechts, Nele
Lambert, Didier M
Verbruggen, Alfons
Van Laere, Koen
Bormans, Guy #
Issue Date: May-2009
Publisher: Pergamon Press
Series Title: Nuclear Medicine and Biology vol:36 issue:4 pages:455-465
Abstract: Introduction: The type 2 cannabinoid (CB2) receptor is part of the endocannabinoid system and has been Suggested as a mediator of several central and peripheral inflammatory processes. Imaging of the CB2 receptor has been unsuccessful so far. We synthesized and evaluated a carbon-11- and a fluorine-18-labeled 2-oxoquinoline derivative as new PET tracers with high specificity and affinity for the CB2 receptor.
ISSN: 0969-8051
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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